Bioethics, Volume 36, Issue 1, Page 25-41, January 2022.

Quantum mechanics as conceived by Niels Bohr and formulated in rigorous terms by John von Neumann is expressed as quantum neuroscience: a description of the relationship between certain conscious experiences of an observer that are described in terms of the concepts of classical physics and neural processes that are described in terms of the concepts of quantum physics. The theory is applied to recent neuroscience data to determine the rapidity of the observer's probing actions that is needed to account (...) for the capacity of a person's mental intentions to influence that person's bodily actions in the intended way. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}. (shrink)

_René Descartes proposed an interactive dualism that posits an interaction between the_ _mind of a human being and some of the matter located in his or her brain. Isaac Newton_ _subsequently formulated a physical theory based exclusively on the material/physical_ _part of Descartes’ ontology. Newton’s theory enforced the principle of the causal closure_ _of the physical, and the classical physics that grew out of it enforces this same principle._ _This classical theory purports to give, in principle, a complete deterministic (...) account of the_ _physically described properties of nature, expressed exclusively in terms of these_ _physically described properties themselves. Orthodox contemporary physical theory_ _violates this principle in two separate ways. First, it injects random elements into the_ _dynamics. Second, it allows, and also requires, abrupt probing actions that disrupt the_ _mechanistically described evolution of the physically described systems. These probing_ _actions are called Process 1 interventions by von Neumann. They are psycho-physical_ _events. Neither the content nor the timing of these events is determined either by any_ _known law, or by the afore-mentioned random elements. Orthodox quantum mechanics_ _considers these events to be instigated by choices made by conscious agents. In von_ _Neumann’s formulation of quantum theory each such intervention acts upon the state of_ _the brain of some conscious agent. Thus orthodox von Neumann contemporary physics_ _posits an interactive dualism similar to that of Descartes. But in this quantum version the_ _effects of the conscious choices upon our brains are controlled, in part, by the known_ _basic rules of quantum physics. This theoretically specified mind-brain connection allows_ _many basic psychological and neuropsychological findings associated with the apparent_ _physical effectiveness of our conscious volitional efforts to be explained in a causal and_ _practically useful way.. (shrink)

Orthodox Copenhagen quantum theory renounces the quest to understand the reality in which we are imbedded, and settles for practical rules describing connections between our observations. Many physicist have regarded this renunciation of our effort describe nature herself as premature, and John von Neumann reformulated quantum theory as a theory of an evolving objective universe interacting with human consciousness. This interaction is associated both in Copenhagen quantum theory and in von Neumann quantum theory with a sudden change that brings (...) the objective physical state of a system in line with a subjectively felt psychical reality. The objective physical state is thereby converted from a material substrate to an informational and dispositional substrate that carries both the information incorporated into it by the psychical realities, and certain dispositions for the occurrence of future psychical realities. The present work examines and proposes solutions to two problems that have appeared to block the development of this conception of nature. The first problem is how to reconcile this theory with the principles of relativistic quantum field theory; the second problem is to understand whether, strictly within quantum theory, a person's mind can affect the activities of his brain, and if so how. Solving the first problem involves resolving a certain non-locality question. The proposed solution to the second problem is based on a postulated connection between effort, attention, and the quantum Zeno effect. This solution explains on the basic of quantum physics a large amount of heretofore unexplained data amassed by psychologists. (shrink)

Arguments pertaining to the mind-brain connection and to the physical effectiveness of our conscious choices have been presented in two recent books, one by John Searle, the other by Jaegwon Kim. These arguments are examined, and it is explained how the encountered difficulties arise from a defective understanding and application of a pertinent part of contemporary science, namely quantum mechanics. The principled quantum uncertainties entering at the microscopic levels of brain processing cannot be confined to the micro (...) level, but percolate up to the macroscopic regime. To cope with the conflict between the resulting macroscopic indefiniteness and the definiteness of our conscious experiences, orthodox quantum mechanics introduces the idea of agent-generated probing actions, each of which specifies a definite set of alternative possible empirically/experientially distinguishable outcomes. Quantum theory then introduces the mathematical concept of randomness to describe the probabilities of the various alternative possible outcomes of the chosen probing action. But the agent-generated choice of which probing action to perform is not governed by any known law or rule, statistical or otherwise. This causal gap provides a logical opening, and indeed a logical need, for the entry into the dynamical structure of nature of a process that goes beyond the currently understood quantum mechanical statistical generalization of the deterministic laws of classical physics. The well-known quantum Zeno effect can then be exploited to provide a natural process that establishes a causal psychophysical link within the complex structure consisting of a stream of conscious experiences and certain macroscopic classical features of a quantum mechanically described brain. This naturally created causal link effectively allows consciously felt intentions to affect brain activity in a way that tends to produce the intended feedback. This quantum mechanism provides an eminently satisfactory alternative to the classical physics conclusion that the physical present is 1 completely determined by the physical past, and hence provides a physicsbased way out of the dilemma that Searle and Kim tried to resolve by philosophical analysis.. (shrink)

Cognitive deficits were produced in rats by different methods of damaging the brain: chronic ingestion of alcohol, causing widespread damage to diffuse cholinergic and aminergic projection systems; lesions (by local injection of the excitotoxins, ibotenate, quisqualate, and AMPA) of the nuclei of origin of the forebrain cholinergic projection system (FCPS), which innervates the neocortex and hippocampal formation; transient cerebral ischaemia, producing focal damage especially in the CA1 pyramidal cells of the dorsal hippocampus; and lesions (by local injection of the (...) neurotoxin, colchicine) of the granule cells of the dentate gyrus. Following chronic alcohol or lesions of the FCPS, transplants of cholinergically rich fetal brain tissue into the terminal areas (neocortex and/or hippocampus) restored performance almost to control levels, with a time course consistent with growth of the transplants and integration with host tissue; transplants of cholinergically poor fetal tissue (hippocampus) were without effect, as were transplants of cholinergically rich tissue into the region containing the nuclei of origin of the FCPS. Grafts of primary cells enriched in glia and cultured neuroblastoma cells into the terminal areas of the FCPS were equally effective, suggesting that there are multiple mechanisms by which neural transplants can restore cognitive function following diffuse cholinergic damage. In contrast, after ischaemia- or neurotoxin-induced damage to CA1 or dentate granule cells respectively, cholinergically rich fetal transplants into the damaged hippocampal formation were ineffective in restoring performance. After ischaemic damage, however, performance was restored by suspension grafts of CA1 cells but not by transplants containing CA3 pyramidal cells or granule cells; and after colchicine damage it was restored by solid grafts containing granule but not CA1 pyramidal cells. Furthermore, electrophysiological evidence has demonstrated functional, graft type-specific host-graft functional neuronal connectivity. Thus, restoration of cognitive function by neural transplants is possible after damage to either diffuse (cholinergic) or point-to-point (intrahippocampal) forebrain systems, but the transplant must be appropriate to the damage to be repaired. Because the different types of brain damage studied provide analogues of human alcoholic dementia, Alzheimer's disease, and heart attack, these results are encouraging with regard to the eventual application of neural transplant surgery to the treatment of cognitive deficits in humans. (shrink)

This chapter contains sections titled: Mothering and the Quest for Certainty Finding Answers to Mothering Questions Both/And Not Either/Or Toward a Pragmatic Approach to Mothering Notes.

In lieu of an abstract, here is a brief excerpt of the content:Seeing the Best of MeJohn ScheumannHi I am John, I am 21 and live in Northern California. I was diagnosed with a brain tumor in March 2005. When I was diagnosed I was 13–year–old, in 7th grade, the school year was nearing its end. I was just starting to hit my stride with my youthful independence. Skipping forward to post surgery: right after, the effects from (...) the surgery were severe. My whole body was weak, I was temporarily paralyzed on the left side of my of my body, I could hardly speak or see. My recovery has been hard, relearning how to do many things again.Now eight years after, I have recovered very well (although it doesn’t always seem like that to me). My “disabilities” are physical and cognitive. My physical issues are that I have very poor balance. My coordination is also poor (especially on my left side). I get fatigued more easily, then that triggers the issues with my balance and coordination even more. Also when I’m fatigued my left arm, leg, and hand can get shaky (which is also know as ataxia). My cognitive issues are that I process information slower, have a bad memory, have trouble finding the right words to say, organizing thoughts, etc.To me I am disabled, I have things that happened to me that effected my body and impaired me in different ways. I am disabled but that’s not all I am, I am still a young growing adult who does things that most people my age do.There are times though were the term disability does not do me justice. The things that happened to me affect me everyday but I act and do things that most people my age do, I go to the gym, walk my dog, hang out with friend, watch sports, etc..... On the surface I appear to be an average able bodied person, my “disabilities” aren’t always visible sometimes till someone gets to know me or see me interact for a while. So people will sometimes not treat me in the way I would like to be treated because of their unknowing. People sometimes expect me or want me to do things I’m not capable of and that can be awkward and upsetting.Other times people see me as your average person my age and I’ll tell them I have a disability they don’t understand the complexity of it and that certain things are difficult for me and only in certain situations, not all the time. They don’t understand the disability is individual to me and one issue is not the same for everyone across the board. This can also be awkward and upsetting at times.Saying all this I understand people will misjudge me and most often people are not being ignorant they are acting the best way they know how and that given the chance they can see the best of me and truly understand who I am and forget the label “disabled.” [End Page E8]Copyright © 2013 The Johns Hopkins University Press... (shrink)

Tough Decisions presents many of the complex medical-ethical issues likely to confront practitioners in critical situations. Through fictional but true-to-life cases, vividly described in clinical terms, the authors force the reader to choose among different courses of action and to confront a range of possible consequences. A two-year-old has been diagnosed with a malignant brain tumor. Who should be allowed to make decisions about the child's surgery and subsequent therapy, and on what basis? A family history of Huntington's (...) disease emerges when a fiancee seeks genetic counseling. Who should be informed? An elderly patient suffers a cardiac arrest. Should "do-not-resuscitate" orders always be followed? How should legal liability affect medical decisions? Other ethical issues considered include surgical complications, patient autonomy, rights of the retarded, informed consent, euthanasia, and the fair allocation of finite resources. Each case presented conveys the drama and pressure of weighing alternatives, and the realistic consequences of the choices made. The authors show that ethical decision-making is not limited to "matters of life and death", and that it is not the decision but the ethical process by which it is made that gives the decision moral integrity. With realistic detail, Tough Decisions brings to life and makes the student share in the many complexities of ethical decision-making when the health and lives of patients are at stake. (shrink)

Patients with advanced Alzheimer's disease experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert has been reported to improve cognitive function in individuals with AD. Here, we report the effects of NBM-DBS on cognitive function in a subject with severe AD. An 80-year-old male with severe AD underwent (...) surgery for bilateral NBM-DBS electrode placement. After 10 weeks of stimulation, Mini-Mental State Examination assessment improved from a score of 5 to 9 points, and assessment using the Alzheimer's Disease Assessment Scale–Cognitive Subscale showed a marked reduction in total score from 43 to 33 points, suggesting cognitive benefits from NBM-DBS. The patient's postoperative course was complicated by a subdural effusion that occurred several days after surgery, with complete recovery. Interestingly, the subject also displayed abnormal thermoregulation with stimulation initiation and stimulation parameter modifications. NBM-DBS may serve as a potential therapy for severe AD patients.Clinical Trial Registration: ChiCTR1900022324. (shrink)

Written over the last two decades, John McDowell's papers, as a whole, deal with issues of philosophy. Specifically, separate groups of essays look at the ethical writings of Aristotle and Plato; moral questions regarding the Greek tradition; interpretations of Wittgenstein's work; and, finally, questions about personal identity and the character of first-person thought and speech.

Much as we would like to conceive empirical thought as rationally grounded in experience, pitfalls await anyone who tries to articulate this position, and ...

John Henry Newman was a theologian and vicar at the university church in Oxford who became a leading thinker in the Oxford Movement, which sought to return Anglicanism to its Catholic roots. Newman converted to Catholicism in 1845 and became a cardinal in 1879. He published widely during his lifetime; his work included novels, poetry and the famous hymn 'Lead, Kindly Light', but he is most esteemed for his sermons and works of religious thought. This volume, first published (...) in 1870, is an ambitious examination of the logical processes that underpin religious faith. Newman discusses how it is possible to believe what cannot be proven empirically, and postulates that the mind has the facility to bridge the logic gap to allow for humans to believe in things that they do not fully comprehend. A lucid and masterful work which remains relevant to contemporary discussions of faith. (shrink)

In this new book, John McDowell builds on his much discussed Mind and World—one of the most highly regarded books in contemporary philosophy.

The religious autobiography of John Henry Newman (1801-1890), in which he discusses his conversion to Roman Catholicism.

v. 1. General introduction to the study of Newman's philosophy.--v. 2. The text.

" John McDowell is one of the most influential philosophers writing today. His work, ranging from interpretations of Plato and Aristotle to Davidsonian semantics, from ethics to epistemology and the philosophy of mind, has set the agenda for many recent philosophical debates. This volume contains the proceedings of the third Münsteraner Vorlesungen zur Philosophie which McDowell delivered in 1999: A lecture, entitled ""Experiencing the World"", introduces into the set of ideas McDowell developed in his groundbreaking book Mind and World. (...) The lecture is followed by ten brief essays, both interpretative and critical, in which students and faculty from the Department of Philosophy at the University of Münster discuss various aspects of McDowell's philosophy. The volume ends with responses by John McDowell. ". (shrink)

This is the second volume of John McDowell's selected papers.

Much as we would like to conceive empirical thought as rationally grounded in experience, pitfalls await anyone who tries to articulate this position, and ...

Genetic testing has historically been performed in the context of chronic disease and cancer diagnostics. The timelines for these tests are typically measured in days or weeks, rather than in minutes. As such, the concept that genetic information might be generated and then used to alter management in the acute setting has, thus far, not been feasible. However, recent advances in genetic technologies have the potential to allow genetic information to be generated significantly quicker. The m.1555A>G genetic variant is present (...) in one in 500 individuals and predisposes to profound hearing loss following the administration of aminoglycoside antibiotics. These antibiotics are used frequently in cases of neonatal sepsis and it is estimated that approximately 180 neonates in the UK are at risk of antibiotic induced hearing loss each year because of this genetic change. Knowledge of this variant in the acute setting would allow clinicians to prescribe alternative antibiotics. The Pharmacogenetics to Avoid Loss of Hearing study will implement a genetic point of care test for the m.1555A>G variant within two major UK based neonatal intensive care units. This represents the first trial of a genetic POCT aimed at altering management in the acute setting. This round table discussion outlines the novel ethical issues faced in the development of this trial and the legal barriers to implementation. We ask five stakeholders to provide their opinions on this trial and their perspectives on the concept of genetic testing in the acute setting.Trial registration numberISRCTN-13704894. (shrink)

As he practices this method, what emerges through the volume is the unity of McDowell’s own views.

Very few biographies of Kant exist. The Neo-Kantian movement renewed interest in his life. During the last half of the 19th century, John Henry Wilbrandt Stuckenberg provided an eminently readable biography of Kant, as seen from a sympathetic, yet detached viewpoint.

The dorsal anterior cingulate cortex is a key node in the human salience network. It has been ascribed motor, pain-processing and affective functions. However, the dynamics of information flow in this complex region and how it responds to inputs remain unclear and are difficult to study using non-invasive electrophysiology. The area is targeted by neurosurgery to treat neuropathic pain. During deep brain stimulation surgery, we recorded local field potentials from this region in humans during a decision-making task requiring (...) motor output. We investigated the spatial and temporal distribution of information flow within the dACC. We demonstrate the existence of a distributed network within the anterior cingulate cortex where discrete nodes demonstrate directed communication following inputs. We show that this network anticipates and responds to the valence of feedback to actions. We further show that these network dynamics adapt following learning. Our results provide evidence for the integration of learning and the response to feedback in a key cognitive region. (shrink)

Though physicalism remains the most popular position in the metaphysics of mind today, there is still considerable debate over how to retain a plausible account of mental concepts consistently with a physicalistic world view. Philip Goff (Australasian Journal of Philosophy 89(2), 191–209, 2011) has recently argued that physicalism cannot give a plausible account of our phenomenal concepts, and that as such, physicalism should be rejected. In this paper I hope to do three things, firstly I shall use some considerations from (...) ontology to rebut Goff’s argument and consider some objections and replies. Secondly, I shall outline a version of a posteriori physicalism about phenomenal consciousness which draws on this particular ontology. Thirdly, I shall give support to this version of physicalism by arguing that it marries well with prominent theories in cognitive science, and has important advantages over other versions of a posteriori physicalism. (shrink)

This classic of Christian apologetics seeks to persuade the skeptic that there are good reasons to believe in God even though it si impossible to understand the Deity fully. First written over a century ago, the _Grammar of Assent _speaks as powerfully to us today as it did to its first readers. Because of the informal, non-technical character of Newman's work, it still retains its immediacy as an invaluable guide to the nature of religious belief. An introduction by Nicholas Lash (...) reviews the background of the _Grammar, _highlights its principal themes, and evaluates its philosophical originality. (shrink)

The essays in this volume were written when John Henry Newman was a Fellow of Oriel College, Oxford. He wrote the first, on biblical miracles "The Miracles of Scripture," in 1825-26, as a relatively young man; the other, "The Miracles of Early Ecclesiastical History," was written in 1842-43. A comparison of the two essays displays a shift in Newman's theological stances. In the earlier essay, Newman argues in accordance with the theology of evidence of his time, maintaining that (...) the age of miracles was limited to those recorded in the Old Testament scriptures and in the Gospels and Acts. He asserts that biblical miracles served to demonstrate the divine inspiration of biblical revelation and to attest to the divinity of Christ. However, with the end of the apostolic age, the age of miracles came to an end; miracles reported from the early ages of the Church Newman dismissed as suspicious and possibly fraudulent. With this view, Newman entered into an ongoing debate between the skepticism of Hume and Paine and its continuation in the utilitarianism of Bentham, on the one hand, and the views of Christian apologists rebutting Hume's arguments, on the other. In "The Miracles of Early Ecclesiastical History," Newman can be seen as coming closer to accepting the doctrines of the Catholic Church. He rejects the stance he took in "The Miracles of Scripture," now arguing for a continuity of sacred history between the biblical and ecclesiastical periods. He had clearly abandoned the position of "evidence theologians" that miracles ended after the time of the Apostles. Newman's movement between the writing of the two essays is essentially a growing into a deeper awareness of the Church as a divine society in whose life miracles and supernatural gifts were to be expected. (shrink)

v. 1. General introduction to the study of Newman's philosophy.--v. 2. The text.

But Joyce did not want his hero to be either Greek or English: he wanted him to be Jewish. To that end, a third archetype, and an actual historical person, comes in: Baruch Spinoza. That Joyce himself was acquainted with Spinoza from fairly early in his career seems indubitable. In 1903 he mentioned him twice in a review of J. Lewis McIntyre's Giordano Bruno.1 Also in 1903 Joyce met Synge in Paris, and the two argued about art. Synge finally told (...) Joyce, who was at this time forging his ironclad esthetic in Aristotelian or Thomistic terms, that he had a mind like Spinoza, a remark that Joyce passed on, presumably with some pride, to his mother and his brother. These are the only times in Joyce's life of which there is any published evidence of a connection between Spinoza and Joyce, and yet, as all readers of Ulysses know, Spinoza is Bloom's philosopher, and in Ulysses as a whole Spinoza plays a greater role than any other philosopher, including Aristotle and St. Thomas who appear, surprisingly, rarely and always, with one exception, in the Stephen Dedalus context. Spinoza is also a presence in Finnegans Wake. The appeal of Spinoza to Joyce both as a man and as a mind must have been considerable. · 1. How well Joyce knew Spinoza at this time is problematical. His review of McIntyre's book, entitled "The Bruno Philosophy," published in the Dublin Daily Express, 30 Oct. 1903 , is done in English style, that is, the reviewer makes assertions as if they were his own when in fact they come from the author of the book under review. Thus when Joyce says, "in his attempt to reconcile the matter and form of the Scholastics . . . Bruno had hardily out forward an hypothesis, which is a curious anticipation of Spinoza" , he is only saying what McIntyre himself had said, as the editors of The Critical Writings point out.In point of fact there is nothing "curious" about Bruno being a precursor of Spinoza. One of Spinoza's early mentors, Francis Van den Ende, introduced him early on to the philosophy of Bruno, who thus became one of the formative influences on Spinoza's thought. John Henry Raleigh, professor of English at the University of California at Berkeley, is the author of Matthew Arnold and American Culture; Time, Place, and Idea: Essays on the Novel; and a forthcoming book on Joyce, The Chronicle of the Blooms: "Ulysses" as Narrative. He is currently writing a book on Sir Walter Scott, "Ivanhoe" and Its Times. (shrink)

In this Very Short Introduction, John H. Holland, one of the leading figures in the field, introduces the key elements and conceptual framework of complexity. From complex physical systems such as fluid flow and the difficulties of predicting weather, to complex adaptive systems such as the diverse and interdependent ecosystems of rainforests, he uses simple examples to illustrate the approach and insights provided by complexity theory.

Throughout his career as a theologian, deacon, priest and cardinal, John Henry Newman remained a committed believer in the value of education. A graduate of Trinity College, Oxford, his own academic experiences shaped his friendships, politics and faith. His Discourses, delivered initially as a series of lectures when he was rector of the newly-established Catholic University of Ireland, inspired a generation of young and talented Catholic scholars. Providing an intelligent but accessible analysis of the relationship between theology and (...) other academic disciplines, the lectures were celebrated in the popular press for dispensing instruction to those who 'had no traditions to guide them in forming a correct estimate of what a university ought to be'. Newman argued that a university should foster the 'diffusion and extension of knowledge' rather than religious or moral training, and that it should prepare students for life in the world. (shrink)

First published in 1994, this scholarly edition of a major Renaissance text is edited and introduced by John Henry Jones, a leading expert on the Faust legend. The English translation of the best-selling German Faust Book of 1587 has long been known as Marlowe's principal source for Dr Faustus. The earliest surviving edition of this translation, published in 1592, is here presented complete, in modern spelling and with a line register for reference, together with full details of all (...) alterations and omissions from the German source. Textual comparisons with Doctor Faustus and with later editions of the English Faust Book provide crucial information in the development of the Faust theme in England and Germany. In an introduction making full use of hitherto unpublished research, Dr Jones offers new arguments both on the dating of Marlowe's play, and on the personal history and probable identity of the original translator of the German Faust Book, known only as 'P. F. Gent'. (shrink)